Verified Solution • 2025–26 Session
moderate
QAIPMT-2008-Ch-2226: NEET 2008 Chemistry - Class 12 AIPMT-2008-Ch-2226 Solution: The relative reactivities of acyl compounds towards…
The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of
Multiple Choice Options
- A Acyl chloride > Ester > Acid anhydride > Amide
- B Acyl chloride > Acid anhydride > Ester > Amide
- C Acid anhydride > Amide > Ester > Acyl chloride
- D Ester > Acyl chloride > Amide > Acid anhydride.
Step-by-Step Verified Solution
The more the basic character of the leaving
group, the lesser is the reactivity the basic
character follows the order
NH 2 � > OR � > RCOO � > Cl �
Hence, the relative reactivities of acyl
compounds towards nucleophilic substitution
follow the order
Acyl halides > Acid anhydride
> Ester > Amide.