Verified Solution • 2025–26 Session moderate

QJEEM23Ch5bbe: JEE Main 2023 Chemistry - Class 12 JEEM23Ch5bbe Solution: The one that does not stabilize 2 and 3 structures of proteins is

The one that does not stabilize 2 ∘^\circ and 3 ∘^\circ structures of proteins is

Multiple Choice Options

  • A −- O −- O −- linkage
  • B −- S −- S −- linkage
  • C van der Waals forces
  • D H-bonding

Step-by-Step Verified Solution

The stabilization of secondary (2°) and tertiary (3°) structures of proteins mainly involves interactions such as disulfide bridges (S-S linkages), van der Waals forces, hydrogen bonding, and hydrophobic interactions.

Option A: O-O linkage is not usually involved in the stabilization of protein structures. Oxygen-oxygen single bonds are generally unstable and rarely observed in nature.

Option B: S-S linkage (disulfide bridges) between cysteine residues in a protein can help stabilize the protein's structure, particularly its tertiary structure.

Option C: Van der Waals forces can contribute to the stabilization of protein structures, particularly in the interior of the protein where they can promote hydrophobic interactions.

Option D: Hydrogen bonding can play a critical role in the formation and stabilization of secondary structures such as alpha-helices and beta-sheets.

Therefore, the correct answer is Option A (-O-O- linkage).

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